Multivariate statistical analysis applied to an IL6 signal transduction model in hepatocytes

Applied Multivariate Statistical Analysis

Mathematical Model of IL-6 signal transduction in Hepatocytes

This work focuses on the role of IL-6 in the hepatic acute phase response. A kinetic model of the signal transduction network in hepatocytes stimulated by IL-6 has been developed. Signaling induced by the IL-6 family of cytokines involves the activation of two major pathways: the JAK (Janus-associated kinases)/ STAT (signal transducers and transcription factors) and the MAPK (mitogen-activated ...

Signal Transduction Applied

is helpful in understanding the importance of the pathIn earlier years, signal transduction research focused ways. For example, the chapter on atherosclerosis emon identifying molecules and pathways. This approach phasizes reactive oxygen and nitric oxide signaling and did not always lead easily to understanding the function the chapter on asthma focuses on the NF B pathway. of a pathway in an ...

An Introduction to Applied Multivariate Analysis

Multivariate Analysis and Reverse Engineering of Signal Transduction Pathways

This thesis presents mathematical and computational approaches to studying signal transduction pathways. The biology of cellular signalling is introduced, highlighting the importance of signalling pathways in regulating the processes of cell division and proliferation. A brief history of mathematical approaches to such systems is presented. Two multivariate analysis methods, principal component...